02431nas a2200277 4500008004100000022001300041245005200054210005100106260001600157300001200173490000800185520164100193653002401834653002201858653002201880653002601902100001401928700001701942700002301959700002901982700001902011700002002030700001702050700002002067856006602087 2017 eng d a0304401700aLice induced immuno-oxidative wreckage of goats0 aLice induced immunooxidative wreckage of goats cJan-08-2017 a24 - 300 v2423 a
The present study aimed to evaluate the immuno-oxidative patho-biology of lice infestation in goats. Sixty goats were divided into five groups; sucking lice (Linognathus africanus) infested (Group 1, n = 12), chewing lice (Bovicola caprae) infested-mild (Group 2, n = 12), chewing lice (B. caprae) infested-moderate (Group 3, n = 12), chewing lice (B. caprae) infested-severe (Group 4, n = 12) and healthy control (Group 5, n = 12). To assess the pathological changes, markers of oxidative stress (lipid peroxidation-LPO, reduced glutathione-GSH, superoxide dismutase-SOD, Catalase-CAT and total antioxidant capacity-TAC), the markers of immune status (Tumour necrosis factor alpha- TNF-α, Interleukin-10- IL-10, Transforming growth factor beta 1- TGF-β1, ratios of TNF-α/IL-10 and TNF-α/TGF-β1) and hemato-biochemical status were evaluated. Significant anemia, hypoglycemia, hypoproteinemia and hypoalbuminemia were observed in caprine pediculosis irrespective of the type of lice infested. Remarkably increased oxidative stress was observed in chewing lice infested goats and no significant changes in oxidative stress markers were observed in sucking lice infested goats. TGF-β mediated suppression of Th1 and Th2 immune responses was observed in sucking lice infested goats; whereas, a Th2 cytokine dominant inflammatory response was observed in chewing lice infested goats. From the present study, it may be concluded that sucking lice infestation produces remarkable immunosuppression and chewing lice infestation produces significant oxidative stress and inflammatory responses in goats.
10aCaprine pediculosis10aCytokine response10aImmunosuppression10aOxidative impairments1 aAjith, Y.1 aDimri, Umesh1 aSingh, Shanker, K.1 aGopalakrishnan, Arumugam1 aDevi, Gopinath1 aVerma, Med, Ram1 aJoshi, Vivek1 aAlam, Shahjahan uhttp://linkinghub.elsevier.com/retrieve/pii/S0304401717302200