<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Burgess,Ian F.</style></author><author><style face="normal" font="default" size="100%">Christine M. Brown</style></author><author><style face="normal" font="default" size="100%">Lee,Peter N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial</style></title><secondary-title><style face="normal" font="default" size="100%">British Medical Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Administration, Topical</style></keyword><keyword><style  face="normal" font="default" size="100%">adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">adult</style></keyword><keyword><style  face="normal" font="default" size="100%">animals</style></keyword><keyword><style  face="normal" font="default" size="100%">child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">Follow-Up Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">humans</style></keyword><keyword><style  face="normal" font="default" size="100%">insecticide</style></keyword><keyword><style  face="normal" font="default" size="100%">Lice Infestations/drug therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pediculus</style></keyword><keyword><style  face="normal" font="default" size="100%">Pyrethrum</style></keyword><keyword><style  face="normal" font="default" size="100%">Research Support, Non-U.S. Gov't</style></keyword><keyword><style  face="normal" font="default" size="100%">scalp dermatoses</style></keyword><keyword><style  face="normal" font="default" size="100%">Siloxanes/administration &amp; dosage</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Outcome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2005</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.phthiraptera.info/sites/phthiraptera.info/files/44641.pdf</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">330</style></volume><pages><style face="normal" font="default" size="100%">1423 - 1426</style></pages><isbn><style face="normal" font="default" size="100%">1468-5833</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;OBJECTIVE: To evaluate the efficacy and safety of 4% dimeticone lotion for treatment of head louse infestation.DESIGN: Randomised controlled equivalence trial. SETTING: Community, with home visits. PARTICIPANTS: 214 young people aged 4 to 18 years and 39 adults with active head louse infestation. INTERVENTIONS: Two applications seven days apart of either 4.0% dimeticone lotion, applied for eight hours or overnight, or 0.5% phenothrin liquid, applied for 12 hours or overnight. OUTCOME MEASURES: Cure of infestation (no evidence of head lice after second treatment) or reinfestation after cure. RESULTS: Cure or reinfestation after cure occurred in 89 of 127 (70%) participants treated with dimeticone and 94 of 125 (75%) treated with phenothrin (difference -5%, 95% confidence interval -16% to 6%). Per protocol analysis showed that 84 of 121 (69%) participants were cured with dimeticone and 90 of 116 (78%) were cured with phenothrin. Irritant reactions occurred significantly less with dimeticone (3/127, 2%) than with phenothrin (11/125, 9%; difference -6%, -12% to -1%). Per protocol this was 3 of 121 (3%) participants treated with dimeticone and 10 of 116 (9%) treated with phenothrin (difference -6%, -12% to -0.3%). CONCLUSION: Dimeticone lotion cures head louse infestation. Dimeticone seems less irritant than existing treatments and has a physical action on lice that should not be affected by resistance to neurotoxic insecticides.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">7505</style></issue><notes><style face="normal" font="default" size="100%">DEP: 20050610; JID: 8900488; 0 (Insecticides); 0 (Pyrethrins); 0 (Siloxanes); 0 (dimeticone); 26002-80-2 (phenothrin); 2005/06/10 [aheadofprint]; ppublish</style></notes></record></records></xml>