<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eyob Girma Abera</style></author><author><style face="normal" font="default" size="100%">Kedir Negesso Tukeni</style></author><author><style face="normal" font="default" size="100%">Gelaw Hailemariam Didu</style></author><author><style face="normal" font="default" size="100%">Temesgen Kabeta Chala</style></author><author><style face="normal" font="default" size="100%">Daniel Yilma</style></author><author><style face="normal" font="default" size="100%">Esayas Kebede Gudina</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Brian Stevenson</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Epistaxis and thrombocytopenia as major presentations of louse borne relapsing fever: Hospital-based study</style></title><secondary-title><style face="normal" font="default" size="100%">PLoS One</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Dec-30-2022</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279721</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">10 pp</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;jats id=&quot;sec001&quot; sec=&quot;&quot;&gt; &lt;jats title=&quot;&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;&lt;/jats&gt;&lt;strong&gt; &lt;/strong&gt;&lt;jats p=&quot;&quot;&gt;Louse-borne relapsing fever (LBRF) remains a cause of sporadic illness and occasional outbreaks in Ethiopia and other east African countries in overcrowded and unhygienic settings. In this article, we present clinical profiles and treatment outcome of patients treated as confirmed or probable cases of LBRF at Jimma Medical Center (JMC) in southwest Ethiopia.&lt;/jats&gt; &lt;/jats&gt;&lt;/p&gt;
&lt;p&gt;&lt;jats sec=&quot;&quot;&gt;&lt;/jats&gt; &lt;jats id=&quot;sec002&quot; sec=&quot;&quot;&gt; &lt;jats title=&quot;&quot;&gt;&lt;strong&gt;Methods&lt;/strong&gt;&lt;/jats&gt; &lt;jats p=&quot;&quot;&gt;Patients treated as confirmed or probable cases of LBRF at JMC during a period of May&amp;ndash;July 2022 were prospectively followed during their course of hospital stay. All patients were evaluated with blood film for hemoparasites, complete blood count, and liver enzymes on hospital presentation. They were followed with daily clinical evaluation during their hospital stay.&lt;/jats&gt; &lt;/jats&gt; &lt;jats id=&quot;sec003&quot; sec=&quot;&quot;&gt; &lt;jats title=&quot;&quot;&gt;&lt;/jats&gt;&lt;/jats&gt;&lt;/p&gt;
&lt;p&gt;&lt;jats sec=&quot;&quot;&gt;&lt;jats title=&quot;&quot;&gt;&lt;strong&gt;Result&lt;/strong&gt;&lt;/jats&gt; &lt;jats p=&quot;&quot;&gt;Thirty-six patients were treated as cases of LBRF. All patients except one were from Jimma Main Prison in Jimma Town, Ethiopia. All the patients were male with mean age of 28.7 years (SD = 12.7). The diagnosis of LBRF was confirmed by detection of &lt;jats italic=&quot;&quot;&gt;B&lt;/jats&gt;. &lt;jats italic=&quot;&quot;&gt;recurrentis&lt;/jats&gt; in blood film of 14 (38.9%) of the patients; the rest were treated as presumptive case of LBRF. Fever, reported by all patients, and an acute onset epistaxis, 30 (83.3%), were the major reasons for healthcare visits. Twenty-two (61.1%) patients were having thrombocytopenia with a platelet count &amp;lt; 150,000/&amp;mu;L; nine (25%) of which had severe forms (&amp;lt;50,000/&amp;mu;L). All patients were treated with oral doxycycline and discharged with improvement after a mean length of hospital stay of 4.25 days (SD = 0.77), range 2&amp;ndash;6 days. Public health emergency was activated within two days of the first cases and helped in delousing all the cases and their contacts.&lt;/jats&gt; &lt;/jats&gt; &lt;jats id=&quot;sec004&quot; sec=&quot;&quot;&gt; &lt;jats title=&quot;&quot;&gt;&lt;/jats&gt;&lt;/jats&gt;&lt;/p&gt;
&lt;p&gt;&lt;jats sec=&quot;&quot;&gt;&lt;jats title=&quot;&quot;&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;&lt;/jats&gt; &lt;jats p=&quot;&quot;&gt;LBRF remains a public health problem in Ethiopia in settings with poor personal hygiene. Patients with LBRF may present with severe thrombocytopenia and life-threatening bleeding. Early detection and treatment initiation prevents outbreak propagation and improves treatment outcome.&lt;/jats&gt; &lt;/jats&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">12 ( e027972)</style></issue><work-type><style face="normal" font="default" size="100%">Open Access - Review</style></work-type></record></records></xml>