@article {96386, title = {First report of classical knockdown resistance (kdr) mutation, L1014F, in human head louse Pediculus humanus capitis (Phthiraptera: Anoplura)}, journal = {Medical and Veterinary Entomology}, volume = {37}, year = {2023}, pages = {209-212}, type = {Short communication}, abstract = {

There are at least three known knockdown resistance (kdr) mutations reported globally in the human head louse Pediculus humanus capitis De Geer (Phthiraptera: Anoplura) that are associated with reduced sensitivity to pyrethroids. However, the prevalence of kdr mutation in head lice is not known in the Indian subcontinent. To identify kdr mutations in the Indian head lice population, the genomic region of the voltage-gated sodium channel gene encompassing IIS1-2 linker to IIS6 segments was PCR-amplified and sequenced from P. humanus capitis samples collected from different geographic localities of India. DNA sequencing revealed the presence of four kdr mutations: M827I, T929I, L932F and L1014F. The presence of a classical kdr mutation L1014F, the most widely reported mutation across insect-taxa associated with the kdr-trait, is being reported for the first time in P. humanus capitis.

}, keywords = {Insecticide resistance, kdr mutation, Pediculosis, Pyrethroid, voltage-gated sodium channel.}, issn = {0269-283X, 1365-2915}, doi = {10.1111/mve.12596}, url = {https://resjournals.onlinelibrary.wiley.com/doi/abs/10.1111/mve.12596}, author = {Prashant K. Mallick and Ankita Sindhania and Toshi Gupta and Dhirendra P. Singh and Seema Saini and Singh,O. P.} }