@article {94485,
	title = {Ivermectin lipid-based nanocarriers as novel formulations against head lice},
	journal = {Parasitology Research},
	volume = {116},
	year = {2017},
	month = {Jan-08-2017},
	pages = {2111 - 2117},
	abstract = {<p>The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of effi- ciently insecticide delivery systems is imperative for the con- trol of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, pre- pared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI \&le; 0.2). The KT50 mor- tality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28\%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effective- ness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.</p>
},
	keywords = {Ivermectin, Lipid nanoparticles, Nanotechnology, Pediculosis},
	issn = {0932-0113},
	doi = {10.1007/s00436-017-5510-2},
	url = {http://link.springer.com/10.1007/s00436-017-5510-2},
	author = {Gabriela Ullio-Gamboa and Santiago Palma and Jean Pierre Benoit and Daniel Allemandi and Picollo,Mar{\'\i}a In{\'e}s and Toloza,Ariel Ceferino}
}
