@article {95163, title = {Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74\%, on Louse Eggs: A Randomized, Double-Blind Study}, journal = {Global Pediatric Health}, volume = {6}, year = {2019}, month = {02-2019}, pages = {7 pp}, type = {Open Access}, abstract = {

Few head lice treatments have demonstrated effectiveness against louse eggs. Abametapir, a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development. In this double-blind, phase 2 study, 50 subjects aged \≥3 years with active head lice infestation were randomized to receive a single treatment of abametapir lotion, 0.74\%, or vehicle (control), applied to scalp and hair for 10 minutes. Ovicidal efficacy was measured by recording the hatch rate of eggs collected from each subject\’s hair before and after treatment and incubated for 14 days. With abametapir, 100\% of treated eggs remained unhatched compared with 64.0\% for vehicle. Accounting for pretreatment hatch rates, the absolute reduction in egg hatching was 92.9\% for abametapir versus 42.3\% for vehicle (P \< .0001). The most frequently reported adverse event was rash (16\%). Abametapir lotion, 0.74\%, demonstrated significant ovicidal activity against head lice eggs with a single application.

}, keywords = {abametapir, clinical, head lice, louse eggs, Ovicidal}, issn = {2333-794X}, doi = {10.1177/2333794X19831295}, url = {http://journals.sagepub.com/doi/10.1177/2333794X19831295}, author = {Bowles,V. M. and Sharon Hanegraaf and Tiina Ahveninen and Srinivas Sidgiddi and Kent Allenby and Hugh Alsop} } @article {94710, title = {Clinical studies evaluating abametapir lotion, 0.74\%, for the treatment of head louse infestation}, journal = {Pediatric Dermatology}, volume = {35}, year = {2018}, month = {July 2018}, pages = {616 - 621}, abstract = {

Background: There is a need for better control of head louse infestations. Abameta- pir is an inhibitor of metalloproteinases critical for louse survival and egg develop- ment. The efficacy of abametapir lotion, 0.74\%, was assessed for its ability to clear head louse infestations after a single application.
Methods: Two randomized, double-blind, multicenter, vehicle-controlled studies were conducted in subjects aged 6 months and older to compare the effectiveness of abametapir lotion versus vehicle control for eliminating head louse infestations without nit combing. Abametapir lotion was applied to dry hair for 10 minutes on day 0 and then rinsed with water. The primary endpoint was the proportion of index subjects (youngest household member with \≥ 3 live lice at screening) in the intent- to-treat population who were louse free at all follow-up visits through day 14. Older household members with one or more live lice at screening were designated as non- index subjects and treated as per the index subject within their household.
Results: In the intent-to-treat population (index subjects, N = 216), 81.5\% of sub- jects treated with abametapir lotion were louse free through day 14 after a single treatment, versus 49.1\% with vehicle (P \< 0.001). For the combined index and non- index population (N = 704), 85.9\% were louse free through day 14 in the abameta- pir group, versus 61.3\% in the vehicle group (P \< 0.001). The most frequently reported adverse events were erythema (4.0\%), rash (3.2\%), and skin burning sensa- tion (2.6\%).
Conclusion: Abametapir lotion, 0.74\%, was effective at clearing active head louse infestations through day 14 in subjects aged 6 months and older. All adverse events (including one serious but unrelated to study drug) resolved uneventfully.

}, keywords = {Infestation, therapy-topical}, doi = {10.1111/pde.13612}, url = {https://onlinelibrary.wiley.com/doi/full/10.1111/pde.13612}, author = {Bowles,V. M. and Lisa Jenkins Van_Luvanee and Hugh Alsop and Lydie Hazan and Katie Shepherd and Srinivas Sidgiddi and Kent Allenby and Tiina Ahveninen and Sharon Hanegraaf} }