@article {94705,
	title = {A New Ivermectin Formulation Topically Kills Permethrin-Resistant Human Head Lice (Anoplura: Pediculidae)},
	journal = {Journal of Medical Entomology},
	volume = {45},
	year = {2008},
	month = {Jan 2008},
	pages = {75 - 81},
	abstract = {<p>This study examines the effectiveness of a new ivermectin formulation for the topical treatment of the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae). Permethrin-resistant lice originally obtained from south Florida and maintained on an in vitro rearing system were 100\% susceptible to ivermectin formulations by using a semiclinical hair tuft bioassay. The formulation was 100\% effective at killing lice using 1, 0.5, and 0.25\% ivermectin concentrations after 10-min exposures. As judged by the lethal time (LT)50 and LT95 values, 0.5\% formulated ivermectin was 3.8 and 3.2 times faster at killing lice, respectively, than 0.5\% nonformulated ivermectin, indicating that the formulation may facilitate the penetration of ivermectin into the louse. The hair tuft-based bioassay in conjunction with the in vitro rearing system provides a standardized method to assess the comparative ef\&THORN;cacy of pediculicide formulations in a reproducible format that mimics the exposure scenario that occurs on the human scalp.</p>
},
	keywords = {human head louse, in vitro rearing system, ivermectin formulation},
	issn = {0022-2585},
	doi = {10.1093/jmedent/45.1.75},
	url = {https://academic.oup.com/jme/article/45/1/75/874003},
	author = {Strycharz,Joseph P. and Kyong Sup Yoon and Clark,J. Marshall}
}
