@article {96127, title = {World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for studies evaluating the efficacy of parasiticides in reducing the risk of vector-borne pathogen transmission in dogs and cats}, journal = {Veterinary Parasitology}, volume = {290}, year = {2021}, month = {Feb-01-2021}, pages = {14 pp}, abstract = {

These guidelines are intended to provide an in-depth review of current knowledge and assist the planning and implementation of studies for evaluating the efficacy of parasiticides in reducing transmission of vector-borne pathogens (VBPs) to dogs and cats. At present, the prevention of VBP transmission in companion animals is generally achieved through the administration of products that can repel or rapidly kill arthropods, thus preventing or interrupting feeding before transmission occurs. The present guidelines complement existing guidelines, which focus on efficacy assessment of parasiticides for the treatment, prevention and control of flea and tick infestations, but also give guidance for studies focused on other vectors (i.e. mosquitoes and phlebotomine sand flies). The efficacy of parasiticides in reducing VBP transmission can be evaluated through laboratory or field studies. As such, the present guidelines provide recommendations for these studies, representing a tool for researchers, pharmaceutical companies and authorities involved in the research, development and registration of products with claims for reducing VBP transmission in dogs and cats, respecting the overall principles of the 3Rs (replacement, reduction and refinement). Gaps in our current understanding of VBP transmission times are herein highlighted and the need for further basic research on related topics is briefly discussed.

}, keywords = {cat, dog, Guidelines, parasiticide, vector-borne pathogen}, issn = {0304-4017}, doi = {10.1016/j.vetpar.2021.109369}, url = {http://dx.doi.org/10.1016/j.vetpar.2021.109369}, author = {Domenico Otranto and Filipe Dantas-Torres and Josephus J. Fourie and Vincenzo Lorusso and Marie Varloud and Luigi Gradoni and Jason Drake and Thomas Geurden and Ronald Kaminsky and Anja R Heckeroth and Bettina Schunack and Pollmeier,M. and Beugnet,F. and Peter Holdsworth} } @article {46051, title = {Evaluation of the efficacy of fipronil formulations in the treatment and control of biting lice, Trichodectes canis (De Geer, 1778) on dogs}, journal = {Veterinary parasitology}, volume = {107}, year = {2002}, note = {LR: 20031114; JID: 7602745; 0 (Aerosols); 0 (Insecticides); 0 (Pyrazoles); 120068-37-3 (fipronil); ppublish}, month = {2002}, pages = {127 - 136}, address = {Netherlands}, abstract = {

The efficacy of FRONTLINE SPRAY (0.25\% (w/v) fipronil), FRONTLINE SPOT-ON FOR DOGS (10\% (w/v) fipronil) and FRONTLINE PLUS FOR DOGS (10\% (w/v) fipronil and 9\% (S)-methoprene) against the biting louse Trichodectes canis on dogs was confirmed under laboratory conditions. A field study evaluated the efficacy of a single topical application of FRONTLINE SPRAY and FRONTLINE SPOT-ON against the parasite on dogs. A total of 48 dogs of mixed breeds, both sexes, aged 2 months-7 years and weighing 1.8-37.0kg were used. The animals were either experimentally (laboratory study) or naturally (field study) infested with lice. Dogs were housed individually in order to prevent contact between animals. In the laboratory study, animals were allocated based on pre-treatment louse counts from 38 hair coat-partings per animal. Dogs were randomly assigned to the four treatment groups: (1) untreated control; (2) FRONTLINE SPRAY, at 6ml/kg; (3) FRONTLINE SPOT-ON as per label and (4) FRONTLINE PLUS as per label. Dogs in treatment groups 2-4 were treated twice topically on Days 0 and 28. The number of live lice in the 38 hair coat-partings per animal were counted on Days 2, 7 and weekly to Day 63. In addition, a whole body comb count was performed on Day 63. No live T. canis were found on dogs treated with FRONTLINE formulations at any post-treatment examination. The difference from controls was significant (P98\% on Day 2 and, 100\% on Days 28 and 42 in all treatment groups. The results of these studies demonstrate that fipronil in topical formulations is effective for treatment and control of biting lice (T. canis) infestations on dogs.

}, keywords = {Administration, Topical, Aerosols, animals, Dog Diseases, insecticide, Lice Infestations/drug therapy/prevention \& control/veterinary, Mallophaga, Pyrazoles, Treatment Outcome}, isbn = {0304-4017}, doi = {https://doi.org/10.1016/S0304-4017(02)00090-0}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0304401702000900}, author = {Pollmeier,M. and Pengo,G. and Jeannin,P. and Soll,M.} } @article {45941, title = {Effective treatment and control of biting lice, Felicola subrostratus (Nitzsch in Burmeister, 1838), on cats using fipronil formulations}, journal = {Veterinary parasitology}, volume = {121}, year = {2004}, note = {CI: Copyright 2004; JID: 7602745; 0 (Insecticides); 0 (Pyrazoles); 114-26-1 (Propoxur); 120068-37-3 (fipronil); 2003/10/17 [received]; 2004/01/27 [revised]; 2004/02/04 [accepted]; ppublish}, month = {2004}, pages = {157 - 165}, publisher = {Elsevier B.V}, address = {Netherlands}, abstract = {

The efficacy of 0.25\% fipronil spray (Frontline Spray, Merial), 10\% fipronil spot-on (Frontline Spot-on for Cats, Merial) and 10\% fipronil/12\% (S)-methoprene (Frontline Plus for Cats, Merial) against the biting louse Felicola subrostratus on cats was assessed and confirmed under laboratory conditions. A field study evaluated the efficacy of a single topical application of Frontline Spray, and spot-on against the parasite on cats. In the laboratory studies, animals were allocated based on pre-treatment louse counts to the treatment groups: (1) untreated control and (2) 10\% fipronil spot-on in the exploratory study or (1) untreated control, (2) 0.25\% fipronil spray, at 6 ml/kg; (3) 10\% fipronil spot-on as per label and (4) 10\% fipronil/12\% (S)-methoprene as per label in the confirmation study. Cats in treatment groups 2-4 were treated twice topically on Days 0 and 28. No live F. subrostratus were found on cats treated with fipronil formulations at any post-treatment examination. The difference from controls was significant (P 98\% on Day 2 and 100\% on Days 28 and 42 in all treatment groups. The results of these studies demonstrate that fipronil in topical formulations is effective for treatment and control of biting lice (F. subrostratus) infestations on cats.

}, keywords = {Administration, Topical, animals, cat, insecticide, lice, Lice Infestations/parasitology/prevention \& control/veterinary, Pyrazoles, Random Allocation}, isbn = {0304-4017}, doi = {https://doi.org/10.1016/j.vetpar.2004.02.012}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0304401704000743}, author = {Pollmeier,M. and Pengo,G. and Longo,M. and Jeannin,P.} } @article {45888, title = {Efficacy of eprinomectin against Linognathus vituli and Bovicola bovis on calves}, journal = {Veterinary Record}, volume = {156}, year = {2005}, month = {2005}, pages = {112 - 113}, keywords = {Administration, Topical, animals, Anoplura, cattle, Cattle Diseases, insecticide, Ivermectin/analogs \& derivatives/pharmacology/therapeutic use, Mallophaga, Time Factors, Treatment Outcome}, doi = {https://doi.org/10.1136/vr.156.4.112}, url = {https://bvajournals.onlinelibrary.wiley.com/doi/10.1136/vr.156.4.112}, author = {Rehbein,S. and Pitt,S. R. and Rossi,L. and Pollmeier,M.} }