@article {46215,
	title = {Differential permethrin susceptibility of head lice sampled in the United States and Borneo},
	journal = {Archives of Pediatric and Adolescent Medicine},
	volume = {153},
	year = {1999},
	month = {1999},
	pages = {969 - 973},
	abstract = {<p>BACKGROUND: Pediculiasis is treated aggressively in the United States, mainly with permethrin- and pyrethrin-containing pediculicides. Increasingly frequent anecdotal reports of treatment failure suggest the emergence of insecticidal resistance by these lice. OBJECTIVE: To confirm or refute the susceptibility of head lice sampled in the United States to permethrin. DESIGN: Survey. Head lice were removed from children residing where pediculicides are readily available and where such products are essentially unknown. Their survival was compared following exposure to residues of graded doses of permethrin in an in vitro bioassay. SETTING: School children from Massachusetts, Idaho, and Sabah (Malaysian Borneo). SUBJECTS: In the United States, 75 children aged 5 to 8 years. In Sabah, 59 boys aged 6 to 13 years. Virtually all sampled US children had previously been treated with pediculicides containing pyrethrins or permethrin; none of the Sabahan children were so exposed. MAIN OUTCOME MEASURE: Survival of head lice exposed to permethrin. RESULTS: Permethrin did not affect head lice sampled from chronically infested US children who had previously been treated for pediculiasis. The slope of the dose-response regression line for these lice did not differ significantly from zero (P = .66). This pediculicide immobilized lice sampled in Sabah. Mortality correlated closely with permethrin concentration (P = .008). CONCLUSIONS: Head lice in the United States are less susceptible to permethrin than are those in Sabah. The pyrethroid susceptibility of the general population of head lice in the United States, however, remains poorly defined. Accordingly, these relatively safe over-the-counter preparations may remain the pediculicides of choice for newly recognized louse infestations.</p>
},
	keywords = {adolescent, animals, Borneo, child, Dose-Response, humans, Idaho, insecticide, Insecticide resistance, Lice Infestations/drug therapy, Linear Models, Massachusetts, Pediculus, Permethrin, Pyrethrum, Research Support, Non-U.S. Gov{\textquoteright}t, scalp dermatoses},
	doi = {10.1001/archpedi.153.9.969},
	url = {https://jamanetwork.com/journals/jamapediatrics/fullarticle/347786},
	author = {Richard J. Pollack and Kiszewski,Anthony and Armstrong,Philip and Hahn,Christine and Wolfe,Nathan and Rahman,Hasan Abdul and Laserson,Kayla and Telford,Sam R., 3rd and Spielman,Andrew}
}
@article {45907,
	title = {Efficacy of a reduced application time of Ovide lotion (0.5\% malathion) compared to Nix creme rinse (1\% permethrin) for the treatment of head lice},
	journal = {Pediatric dermatology},
	volume = {21},
	year = {2004},
	note = {JID: 8406799; 0 (Insecticides); 121-75-5 (Malathion); 52645-53-1 (Permethrin); ppublish},
	month = {2004},
	pages = {670 - 674},
	address = {United States},
	abstract = {<p>Our objective was to conduct a randomized, investigator-blinded evaluation of the pediculicidal and ovicidal activity of a reduced application time (20 minutes) of Ovide (0.5\% malathion) compared to Nix (1\% permethrin) in a south Florida population infested with Pediculus humanus capitis. Either Ovide or Nix was applied according to the label instructions. However, Ovide application time was reduced to 20 minutes. At day 8, subjects with live lice were re-treated with the same product and procedure as on day 1. Ovicidal and pediculicidal efficacy were evaluated at days 8 and 15. A subject free of lice and viable eggs at day 15 was considered to be a treatment success. Percent efficacy was calculated using the number of subjects free of lice and viable eggs per total number of subjects treated. We found that a 20-minute application of Ovide was significantly more pediculicidal and ovicidal (98\%) compared to Nix (55\%) at day 15 (p \&lt; 0.0001). The percentage of Ovide subjects who required treatment at day 8 was half that of the Nix group. The reinfestation rate was 0\% with Ovide and 33\% with Nix. In conclusion, a 20-minute treatment with Ovide, instead of the approved 8- to 12-hour application, cured 40 of 41 subjects (98\%), demonstrating superior efficacy to Nix. The poor efficacy of Nix confirms the resistance of head lice to permethrin in south Florida.</p>
},
	keywords = {adolescent, adult, Aged, animals, child, Comparative Study, Dose-Response, Florida, humans, insecticide, Lice Infestations/drug therapy, Malathion, Middle Aged, Pediculus, Permethrin, Research Support, Non-U.S. Gov{\textquoteright}t, scalp dermatoses, Single-Blind Method, Treatment Outcome},
	isbn = {0736-8046},
	doi = {https://doi.org/10.1111/j.0736-8046.2004.21613.x},
	url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.0736-8046.2004.21613.x},
	author = {Meinking,Terri Lynn and Vicaria,M. and Eyerdam,D. H. and Villar,M. E. and Reyna,S. and Suarez,G.}
}
