@article {94743, title = {Efficacy and Safety of a Water-Based Head Lice Lotion: A Randomized, Controlled, Investigator-Blinded, Comparative, Bicentric Study}, journal = {Dermatology and Therapy}, volume = {9}, year = {2019}, month = {03-2019}, pages = {143 - 157}, abstract = {

Introduction:\ Silicones (e.g., dimethicone) are effective and safe alternatives to insecticides for the treatment of head lice. However, silicones are lipophilic substances and do not only leave the hair greasy but they are also difficult to wash out. We have evaluated the efficacy and safety of a potential solution to this problem: an aqueous dispersion of a novel silylated polyol that has the same mode of action as dimethicone (suffocation) without its negative impact on hair characteristics.

Methods:\ This was a randomized, controlled, investigator-blinded, bicentric study that was conducted at two locations in the state of Florida (USA) to compare the test product (medical device) to a pyrethrum-based pediculicide that is a first-line, prescription-free treatment against head lice in the USA. The subjects (n\ =\ 70) were randomly divided into two groups of 35 persons (test product group and reference product group), with each participant receiving two applications (day 0 and 7) of the product to be tested, according to the instructions for use. Efficacy and safety was evaluated at distinct time points. The primary objective was to establish a cure rate for the test product that was better than 70\% at study end (day 10). Esthetic effects of the test product versus dimethicone were evaluated in a blinded, cross-over consumer study (n\ =\ 100).

Results:At study end, the cure rate (corrected for re-infestation) of 88.2\% with the test product significantly surpassed the pre-defined target of 70\%, and thus the superiority of the test product versus the reference product was confirmed. The number of subjects cured (free of head lice) after the first treatment was remarkably higher with the test product than with the reference product (57.1 vs. 2.9\%, respectively). Both products were safe and well tolerated and both showed beneficial esthetical effects. The consumer test demonstrated that the test product had better washing-out properties than dimethicone, as reflected by a significantly lower average rinsing time and number of washings required to restore the visual aspect of the hair, especially in terms of greasiness.

Conclusion:\ Aqueous dispersions of silylated polyols are a promising new class of pediculicides that combine high cure rates with optimal user convenience (short treatment period, easy wash-out with positive effect on hair quality).

}, keywords = {Aqueous-based, Comparative trial, Pediculosis capitis, Pyrethrum, Silylated polyol}, issn = {2193-8210}, doi = {10.1007/s13555-018-0274-x}, url = {http://link.springer.com/10.1007/s13555-018-0274-x}, author = {Frank Eertmans and Bart Rossel and Serrano,L. and Rivera,E. and Els Adriaens} } @article {46065, title = {Comparative in vitro pediculicidal efficacy of treatments in a resistant head lice population in the United States}, journal = {Archives of Dermatology}, volume = {138}, year = {2002}, month = {2002}, pages = {220 - 224}, abstract = {

OBJECTIVE: To compare the pediculicidal activity of 5 head lice products available in the United States on head lice from south Florida.

DESIGN: In vitro pediculicidal product comparison.

SETTING: Lice Source Services, Inc, located in Plantation, Fla, a clinic for the treatment and grooming of individuals with pediculosis capitis.

PARTICIPANTS: Head lice were collected from healthy clients with Pediculus capitis that came to Lice Source Services, Inc, to seek their services.

INTERVENTIONS: Within 2 to 6 hours of capture, lice were placed in continuous direct contact with the pediculicide products and observed at regular intervals. Results were compared with findings of a recent study of a treatment-sensitive population of head lice conducted in Panama.

MAIN OUTCOME MEASURE: Percentage of lice dead at regular observation intervals between 5 minutes and 3 hours of continuous exposure to the pediculicides.

RESULTS: Two prescription products, Ovide lotion (0.5\% malathion) and 1\% lindane shampoo, were ranked in the same order as in 2 previous studies (first and last, respectively). The order of effectiveness from most to least effective was as follows: Ovide lotion, A-200 shampoo (a natural pyrethrin product synergized with piperonyl butoxide), undiluted Nix (1\% permethrin), diluted Nix, RID (a natural pyrethrin product synergized with piperonyl butoxide), and 1\% lindane shampoo.

CONCLUSIONS: There were statistically significant differences in the efficacy of all the products when compared with the results found in the recent study in Panama, except for Ovide lotion. Of those tested, Ovide was the only pediculicide in the United States that had not become less effective. The difference in efficacy of 1\% lindane, Nix, and pyrethrins between the Panama and Florida studies supports the argument that some head lice in the United States have become resistant to these treatments.

}, keywords = {adult, animals, child, Comparative Study, hair, humans, In Vitro, insecticide, Insecticide resistance, Kerosene, Lice Infestations/drug therapy, Lindane/pharmacology, Malathion, Pediculus, Piperonyl Butoxide, Pyrethrum, Research Support, Non-U.S. Gov{\textquoteright}t, scalp dermatoses}, doi = {10.1001/archderm.138.2.220}, url = {https://jamanetwork.com/journals/jamadermatology/fullarticle/478698}, author = {Meinking,Terri Lynn and Serrano,L. and Hard,B. and Entzel,P. and Lemard,G. and Rivera,E. and Villar,M. E.} }