03033nas a2200337   4500008004100000245012200041210006900163260000900232300001600241490000700257520182700264653001202091653001702103653001102120653002002131653002102151653001502172653001502187653001602202653007702218653000902295653004602304653003802350653004802388653004002436653002102476100002102497700001802518700001802536856014102554       1996                        eng d00aField evaluation of doramectin for treatment of gastrointestinal nematode infections and louse infestations of cattle0 aField evaluation of doramectin for treatment of gastrointestinal  c1996  a1468 - 14710 v573 aOBJECTIVE: To evaluate the safety and efficacy of doramectin given by injection at a dosage of 200 micrograms/kg of body weight for treatment of gastrointestinal nematodiasis or louse infestations of cattle.ANIMALS: 1,031 mixed-breed cattle were treated in the nematode study and 418 were treated in the louse study. PROCEDURE: Naturally parasitized cattle were given 200 micrograms of doramectin/kg or an equivalent volume of saline solution, SC. In nematode experiments, fecal samples were collected from each animal 1 week before treatment, at time of treatment, and at weekly intervals there after for 3 weeks. In louse experiments, louse counts were carried out for each animal on the day of treatment and 14 and 28 days later. All cattle were weighted at the time of treatment and at the end of the experiment. 
RESULTS: By 21 days after doramectin treatment, fecal egg counts had decreased to zero in 9 of 10 experiments and to 1 egg/g in the remaining experiment. Differences between treatment groups were significant (P < 0.0001) in all instances. Pretreatment coproculture identified Haemonchus, Ostertagia, Cooperia, Trichostrongylus, and Nematrodirus as the represented genera. Doramectin was 100% effective in eliminating infestation with Linogna thus vituli, Haematopinus eurysternus, and Solenopotes capillatus. Infestation with the chewing louse Damalinia bovis was reduced overall by 86%. For all species, post treatment louse counts were significantly (P < 0.02) less for doramectin-treated cattle than for controls. Adverse reactions to doramectin were not apparent in either study. 
CONCLUSION AND CLINICAL RELEVANCE: Injectable doramectin at a dosage of 200 micrograms/kg is safe and effective for treatment of gastrointestinal nematodiasis and louse infestations of cattle under field conditions.
10aanimals10aanthelmintic10acattle10aCattle Diseases10agastrointestinal10aHaemonchus10aInjections10ainsecticide10aIvermectin/administration & dosage/analogs & derivatives/therapeutic use10alice10aLice Infestations/drug therapy/veterinary10aNematoda/isolation & purification10aNematode Infections/drug therapy/veterinary10aOstertagia/isolation & purification10aTrichostrongylus1 aPhillips, F., E.1 aLogan, N., B.1 aJones, R., M.  uhttps://phthiraptera.myspecies.info/content/field-evaluation-doramectin-treatment-gastrointestinal-nematode-infections-and-louse-infesta