| Publication Type: | Journal Article |
| Year of Publication: | 2021 |
| Authors: | F. Mancini, Villa, L., Menegon, M., di Luca, M., Toma, L., de Liberato, C., Magliano, A., Romiti, F., Carattoli, A., Ciervo, A. |
| Journal: | Annali dell' Istituto Superiore di Sanità |
| Volume: | 57 |
| Issue: | 1 |
| Pagination: | 33-36 |
| Date Published: | March 2021 |
| Keywords: | Acinetobacter spp, carbapenem resistance, Italy, metagenomics, metallo-β-lactamases, NDM-1, OXA |
| Abstract: | Background: The spread of carbapenems resistance is a public health concern. The main group of carbapenemases encoding the β-lactamases activity (bla genes) is the Metallo-β-lactamases (MBLs). Methods. The presence of carbapenemase blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, blaOXA-58-like, and blaNDM-1 genes was screened by real time PCR in 26 Pediculus humanus insects identified from second-hand clothes in a local market in Central Italy. Bacteria diversity was also characterized through shotgun metagenomic amplification for a deep sequencing of the host-associated bacterial microbiomes. Results. The blaOXA-23 and blaNDM-1 carbapenemases genes were found and metagenomic analysis showed a great presence of Acinetobacter species. Conclusions. These results suggest a new potential transmission path for carbapenemase gene spread through bacteria ingested by insects infesting humans. |
| URL: | https://annali.iss.it/index.php/anna/article/view/1187 |
| DOI: | 10.4415/ANN_21_01_05 |
First evidence of blaNDM-1 and blaOXA-23 carbapenemase genes in human body lice infesting a second-hand T-shirt in a street market in Italy
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