Publication Type: | Journal Article |
Year of Publication: | 2021 |
Authors: | H. Oumarou_Hama, Hamada, A., Aboudharam, G., Ghigo, É., Drancourt, M. |
Journal: | Microbial Pathogenesis |
Volume: | 153 |
Issue: | 104797 |
Date Published: | Apr-01-2021 |
ISSN: | 0882-4010 |
Abstract: | Bartonella quintana is a facultative intracellular bacterium responsible for relapsing fever, an example of non-sterilizing immunity. The cellular sanctuary of B. quintana in-between febrile relapses remains unknown but repeated detection of B. quintana in dental pulp specimens suggested long-term half-life dental pulp stem cells (DPSCs) as candidates. As the capacity of DPSCs to internalize microscopic particles was unknown, we confirmed that DPSCs internalized B. quintana bacteria: Gimenez staining and fluorescence microscopy localized B. quintana bacteria inside DPSCs and this internalization did not affect the cellular multiplication of DPSCs during a one-month follow-up despite the increase in the bacterial load. B. quintana-infected DPSCs did not produce Tumor Necrosis Factor-α whereas an important production of Monocytes Chemoattractant Protein-1 was observed. These unprecedented observations suggest the possibility that DPSCs are shelters for the long-term persistence of B. quintana in the host, warranting further experimental and clinical investigations. Attachment is the Preprint version posted online on bioRxiv May 2020.doi: https://doi.org/10.1101/2020.05.13.094037, https://www.biorxiv.org/content/10.1101/2020.05.13.094037v1.full.pdf+html |
URL: | https://www.sciencedirect.com/science/article/abs/pii/S0882401021000693 |
DOI: | 10.1016/j.micpath.2021.104797 |
Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana
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