Lice induced immuno-oxidative wreckage of goats

Publication Type:Journal Article
Year of Publication:2017
Authors:Y. Ajith, Dimri, U., Singh, S. K., Gopalakrishnan, A., Devi, G., Verma, M. Ram, Joshi, V., Alam, S.
Journal:Veterinary Parasitology
Pagination:24 - 30
Date Published:Jan-08-2017
Keywords:Caprine pediculosis, Cytokine response, Immunosuppression, Oxidative impairments

The present study aimed to evaluate the immuno-oxidative patho-biology of lice infestation in goats. Sixty goats were divided into five groups; sucking lice (Linognathus africanus) infested (Group 1, n = 12), chewing lice (Bovicola caprae) infested-mild (Group 2, n = 12), chewing lice (B. caprae) infested-moderate (Group 3, n = 12), chewing lice (B. caprae) infested-severe (Group 4, n = 12) and healthy control (Group 5, n = 12). To assess the pathological changes, markers of oxidative stress (lipid peroxidation-LPO, reduced glutathione-GSH, superoxide dismutase-SOD, Catalase-CAT and total antioxidant capacity-TAC), the markers of immune status (Tumour necrosis factor alpha- TNF-α, Interleukin-10- IL-10, Transforming growth factor beta 1- TGF-β1, ratios of TNF-α/IL-10 and TNF-α/TGF-β1) and hemato-biochemical status were evaluated. Significant anemia, hypoglycemia, hypoproteinemia and hypoalbuminemia were observed in caprine pediculosis irrespective of the type of lice infested. Remarkably increased oxidative stress was observed in chewing lice infested goats and no significant changes in oxidative stress markers were observed in sucking lice infested goats. TGF-β mediated suppression of Th1 and Th2 immune responses was observed in sucking lice infested goats; whereas, a Th2 cytokine dominant inflammatory response was observed in chewing lice infested goats. From the present study, it may be concluded that sucking lice infestation produces remarkable immunosuppression and chewing lice infestation produces significant oxidative stress and inflammatory responses in goats.

Short Title:Veterinary Parasitology
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